Synaptotoxicity of Alzheimer Beta Amyloid Can Be Explained by Its Membrane Perforating Property

Synaptotoxicity of Alzheimer Beta Amyloid Can Be Explained by Its Membrane Perforating Property

The mechanisms that induce Alzheimer's disease (AD) are largely unknown thereby deterring the development of disease-modifying therapies. One working hypothesis of AD is that Abeta excess disrupts membranes causing pore formation leading to alterations in ionic homeostasis. However, it is largely unknown if this also occurs in native brain neuronal membranes. Here we show that similar to other ...

Alzheimer disease therapy: can the amyloid cascade be halted?

Experimental Alzheimer Drugs Targeting Beta- Amyloid and the “Amyloid Hypothesis”

What is beta-amyloid? Beta-amyloid is a small piece of a larger protein called “amyloid precursor protein” (APP). Although scientists have not yet determined APP’s normal function, they have learned a great deal about how it appears to work. In its complete form, APP extends from the inside to the outside of brain cells by passing through a fatty membrane around the cell. When APP is “activated...

How much in the Universe can be explained by geometry ?

The paper uses geometrical arguments to derive equations with relevance for cosmology; 5-dimensional spacetime is assumed because it has been shown in other works to provide a setting for significant unification of different areas of physics. Monogenic functions, which zero the vector derivative are shown to effectively model electrodynamics and relativistic dynamics if one allows for space cur...

Can Nomenclature for the Body be Explained by Embodiment Theories?

According to widespread opinion, the meaning of body part terms is determined by salient discontinuities in the visual image; such that hands, feet, arms, and legs, are natural parts. If so, one would expect these parts to have distinct names which correspond in meaning across languages. To test this proposal, we compared three unrelated languages-Dutch, Japanese, and Indonesian-and found both ...